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The research of lowering the blood sugar about the Young Buckwheat Leaves Powder
 

Unit: Depatment of Pharmacology in Beijing University of Chinese Medicine and Pharmacology
Director of the lab: Sun Janning
Director of the research: Sun Janning
Others : Zhang shuofeng , Wu jinying, Jia Zhanhong
Date: Nov桪ec, 2005
Contact : Sun Janning (Mob:13601224329

Company: Hengshui Shanzhi Health Drink CO.,LTD
Notice: the English content is only the original content's translation. If you want to know the original content, please look through the Chinese conten
The influence of the foundation blood sugar value of the Young Buckwheat Leaves Powder to the streptozotocin causing blood sugar of the small rat goes up.
Purpose
The streptozotocin can hurt insular B-cell, causing the blood sugar to increase high, form the diabetes model. This experiment observation is subjected to the reagent to the influence of the foundation blood sugar value of the Young Buckwheat Leaves Powder to the streptozotocin causing blood sugar of the small rat goes up.
The material of experiment
1.Medicine:
Be subjected to the reagent : the Young Buckwheat Leaves Powder, which provided by Hengshui Shanzhi Health Drink CO., LTD, dark green powder, the dosage is 3--6 gs/ person/ day, in the light of 60 kg weight calculation, is 0.05g /kg. The small rat is subjected to try the amount of: 1g , 0.5g , 0.25g / kg.
The masculine gender checks against the medicine : Metformin Hydrochloride Tablet, LT0412062 , the product Sino-American Shanghai Squibb Pharmaceuticals Ltd , batch number:LT0412062, the small rat is subjected to try the amount of: 0.3g /kg.
Building the high blood sugar model medicine : Streptozotocin, buy from America Sigma CO.,LTD, the dose of building the mold is 150 mg/ kg.
2.Animal:
Small rat of ICR with the weight of 18- -20 g , half is female, half is male, providing by Beijing Vital River Laboratorium Animalis Ltd, qualified certificate number: 2002--2003 of SCXK(Beijing)
3.Instrument:

Ultra Blood Glucose Monitoring System : specification model number:010-635-01, the product of Life Scan International Inc

One Touch Ultra Test Strips : the product of Life Scan International Inc.

The method and result

1.Dividing the groups with medicine:

The small rat is divided into six groups: comparison group, model group, Metformin Hydrochloride Tablet 0.3g /kg/group , the Young Buckwheat Leaves Powder is 1g , 0.5g , 0.25g /kg/group. Each group starts to infuse the medicine to stomach after seventh day of building the mold, giving medicine 14 times, everyday once. The comparison group infuses with same quantity drinking water to the stomach.

2.The method of building the high blood sugar model:

In addition to comparison group, each group small rat forbids to eat after 12 hours, the belly cavity injects the plain 150 mg/ kg of the streptozotocin, returning of feeding in cage.

3.Method:

After 30 minutes of each small rat giving medicine at the end time, behind stopping the medicine four, nine days(16 hours of forbidding the food and water), the tail point puts out minim blood, placing it on the One Touch Ultra Test Strips easure the empty stomach blood sugar with the blood sugar instrument. Compute the average blood sugar value of each group, the criterion value, compared with the comparison group, inspect by t.

4.Result:

The result as following table 1:

The table 1 shows that the influence of Young Buckwheat Leaves Powder to the streptozotocin with the result that the blood sugar goes up the small rat foundation blood sugar value (Unit: mmol/L)

group

dose ( g/kg )

animal quantity

the blood sugar after 14 days dose

the blood sugar after 4 days no dose

the blood sugar after 9 days no dose

modle group

-

10

6.38±0.78

18.93±4.16

16.79±5.74

Young Buckwheat Leaves Powder group

1

10

5.38±0.85*

10.97±4.50**

14.17±4.53

 

0.5

10

6.28±1.20

11.78±2.80**

12.67±3.22

 

0.25

10

6.62±1.28

16.28±6.34

21.85±7.70

Metformin Hydrochloride Tablet

0.3

10

5.34±13.10**

17.94±4.83

22.28±6.14

comparison group

-

16

5.11±0.60**

6.13±0.63**

5.32±0.65**

Annotation: compared with the modle group **P<0.01 , *P<0.05

The results show that: The streptozotocin can hurt the insular B-cell ,causing the blood sugar to increase high, form diabetes model. The small rat foundation blood sugar value is obvious higher than the comparison group. After the medicine infusing to the stomach with the Young Buckwheat Leaves Powder 1 or 0.5g /kg 14 days no dose, the foundation blood sugar value of small rat is lower than the model group. Among them, the Young Buckwheat Leaves Powder with function 1g / kg is most obvious. ( compare with the model group P<0.05), the foundation blood sugar value of small rat is lower than the model group(compare with the model group P<0.01). After the medicine infusing to the stomach with the Young Buckwheat Leaves Powder 1 or 0.5g /kg 9 days no dose, the foundation blood sugar value of small rat is also lower than the model group, there is no obvious difference of statistics.

The results of research shows that: the Young Buckwheat Leaves Powder with 1 or 0.5g /kg (the dose is clinic person's 10 or 20 times) after 14days continuum take medicine, the influence of Young Buckwheat Leaves Powder to the streptozotocin with the result that the blood sugar goes up the small rat foundation blood sugar value, and after no dose the influence can continue 4—9days.

Only a short time with the dose of the Young Buckwheat Leaves Powder, the animals with experiment have shown the effect of lower the blood sugar. Meanwhile, the Young Buckwheat Leaves Powder has the character of plant, has the good effect of the people who has the diabetes and taken the Young Buckwheat Leaves Powder.

Conclusion: the experiment above has shown that the Young Buckwheat Leaves Powder has the obvious effect to lower the blood sugar. Even if there is no dose after 9days, the balance of blood sugar is also can keep, showing the obvious difference from other medicine. As the health effect and mechanism of the Young Buckwheat Leaves Powder, there is a possibility that the connection of Rutin, Buckwheatlitol, γ —Linoleic acid, Chromium and so on effect ingredient, this is looking forward the further discussion.

 
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